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Biochemistry: Master Syllabus & Linked Study Notes

Part of: Biochemistry
13 Syllabus Chapters
45 Linked Topics
98 Scientific Figures
📚 Official Curriculum & Master Syllabus

🧪 Biochemistry: Syllabus & Course Map

Explain the molecules of a cell and the reactions by which those molecules are broken for energy, rebuilt, and switched between fed, fasted, and starved states.

13 Syllabus Modules
45 Mapped Topics
13 Chapter Pages
🗺️ View Course Map 📚 Chapter Pages (13)
CURRICULUM ROADMAP

Interactive Syllabus & Modular Structure

Official curriculum mapped to university degree syllabi and competitive examinations. Each module links directly to its dedicated study notes page and relevant subtopics.

13 Modules
Module 01 Notes →

Water, pH, and buffers

Polarity and hydrogen bonds hydrophobic effect pH, pKa, Henderson–Hasselbalch blood and cell buffers
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Module 02 Notes →

Amino acids and protein structure

Side-chain classes peptide bond primary to quaternary structure helix, sheet, turns folding and chaperones haemoglobin
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Module 03 Notes →

Enzymes

Active site transition state Michaelis–Menten Lineweaver–Burk reversible inhibition allostery vitamins and cofactors phosphorylation and zymogens
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Module 04 Notes →

Carbohydrates

Monosaccharides, anomers, glycosidic bonds disaccharides storage and structural polysaccharides glycoproteins
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Module 05 Notes →

Lipids

Fatty acids and melting triacylglycerols glycerophospholipids and sphingolipids cholesterol micelles, bilayers, fluidity
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Module 06 Notes →

Nucleic acids as molecules

Nucleotides and the phosphodiester Chargaff and Watson–Crick pairs grooves A, B, and Z RNA hairpins denaturation and Tm
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Module 07 Notes →

Bioenergetics

ΔG and equilibrium ATP group transfer coupled reactions NAD and FAD catabolism and anabolism
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Module 08 Notes →

Glycolysis, pyruvate dehydrogenase, and the citric acid cycle

The ten steps and their yields anaerobic pyruvate PDH cofactors and regulation cycle yield anaplerosis
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Module 09 Notes →

Electron transport and oxidative phosphorylation

Complexes and proton pumping ubiquinone and cytochrome c chemiosmosis ATP synthase P/O and shuttles uncouplers inhibitors by site
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Module 10 Notes →

Other carbohydrate pathways

Gluconeogenic bypasses fructose 2,6-bisphosphate Cori cycle glycogen and hormones pentose phosphate pathway and the red cell
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Module 11 Notes →

Lipid metabolism

Lipolysis carnitine shuttle β-oxidation yield ketone bodies fatty-acid synthesis cholesterol and statins lipoproteins
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Module 12 Notes →

Nitrogen metabolism

Transamination and PLP glutamate dehydrogenase urea cycle links to the citric acid cycle glucogenic and ketogenic amino acids one-carbon metabolism nucleotides
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Module 13 Notes →

Integration of metabolism

Organ fuels fed, fasted, and starvation insulin, glucagon, adrenaline, cortisol type 1 diabetes and ketoacidosis
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Core Learning Outcomes & Competencies

Upon mastery of this comprehensive syllabus, students and researchers are expected to:

✓ Use the Henderson–Hasselbalch equation to explain bicarbonate buffering in blood, and say why histidine both buffers and catalyses near neutral pH.
✓ Classify the twenty amino acids by side chain, describe the four levels of protein structure, and explain haemoglobin cooperativity, the Bohr effect, and the action of 2,3-bisphosphoglycerate.
✓ Interpret Km, Vmax, and kcat, distinguish competitive, uncompetitive, and non-competitive inhibition, and give one example each of allosteric control, phosphorylation, and zymogen cleavage.
✓ Compare storage and structural polysaccharides, and relate fatty-acid saturation and cholesterol to bilayer fluidity without invoking transport proteins.
✓ Account for the ATP, NADH, and GTP changes in glycolysis, pyruvate oxidation, and one turn of the citric acid cycle, and explain why complete oxidation of glucose yields about 30 ATP, not 36–38.
✓ Trace the bypasses of gluconeogenesis, the control of glycogen by glucagon, adrenaline, and insulin, and the role of NADPH from the pentose phosphate pathway in the red cell.
✓ Follow a saturated fatty acid through activation, the carnitine shuttle, and β-oxidation; explain when ketone bodies are made and why liver does not use them; and contrast lipoprotein classes by cargo and direction.
✓ Describe the urea cycle’s inputs and ATP cost, the folate and B12 dependence of one-carbon metabolism, and how liver, muscle, adipose, and brain share fuels, including the chemistry of type 1 ketoacidosis.
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