T Cell Activation

T cell activation is a complex process by which T cells are activated by antigen-presenting cells (APCs) in order to mount an immune response against foreign antigens. The process of T cell activation involves several steps:

  1. Antigen Presentation: APCs, such as dendritic cells, macrophages, or B cells, present foreign antigens to T cells. Antigens are typically processed and presented to T cells in the form of short peptide fragments bound to major histocompatibility complex (MHC) molecules.
  2. T Cell Receptor (TCR) Recognition: T cells express TCRs on their surface that recognize specific peptide-MHC complexes presented by APCs. TCR binding to peptide-MHC complexes initiates T cell activation.
  3. Co-stimulation: In addition to TCR recognition, T cell activation requires co-stimulatory signals provided by APCs. Co-stimulatory molecules, such as CD80 and CD86, are expressed on the surface of APCs and interact with co-stimulatory receptors, such as CD28, on T cells.
  4. Signal Transduction: TCR recognition and co-stimulation initiate signal transduction pathways in T cells that lead to activation of transcription factors and changes in gene expression. This results in the production of cytokines and other effector molecules that mediate T cell functions.
  5. Clonal Expansion and Differentiation: Upon activation, T cells undergo clonal expansion, resulting in the proliferation of a large number of T cells specific for the antigen. Activated T cells also differentiate into effector T cells with distinct functions, such as helper T cells, cytotoxic T cells, or regulatory T cells, depending on the signals received during activation.
  6. Memory T Cell Formation: After the immune response has resolved, a subset of activated T cells differentiate into long-lived memory T cells that provide long-term protection against future infections with the same antigen.

T cell activation is a tightly regulated process that requires proper coordination of multiple signaling pathways. Dysregulation of T cell activation can lead to immune dysfunction, autoimmunity, or immunodeficiency.