Genetic drift and gene flow are two important mechanisms that can alter the genetic makeup of a population over time.

Genetic drift is a random process that can occur in small populations where chance events, such as random mating or the death of individuals, can lead to changes in allele frequencies over time. Genetic drift is more pronounced in smaller populations because chance events have a greater impact on the gene pool. Over time, genetic drift can lead to the fixation of alleles, where one allele becomes fixed and the other is lost from the population.

Gene flow, on the other hand, occurs when individuals or their gametes move between populations, bringing new alleles with them. This can increase genetic variation within a population and reduce genetic differences between populations. Gene flow can occur through migration, the movement of individuals between populations, or through the movement of gametes through pollination or other means.

Both genetic drift and gene flow can have significant effects on the genetic makeup of populations and can alter the course of evolution in different ways. Genetic drift can lead to the loss of genetic variation and the fixation of harmful or neutral alleles, while gene flow can introduce new genetic variation and increase the adaptive potential of populations.